I have been thinking there has been a trade off for about a year now, but your discovery of the patent and the publishing of it by BioNTech scientists confirmed it for me. Although many say the LNPs or endotoxin are the adjuvants, I believe it is either dsRNA or rDNA that are acting as the adjuvants.
So the manufacturers NEED to have it a little bit "dirty" in order to get an immune response.
See also the brilliant work by Ganna Petruk and her team showing the intimate binding of mRNA, dsDNA to Endotoxin and the impact on casualty rates. They deserve a Nobel Prize.
When reading books by cutting-edge specialists, there are still many things we don't understand about various RNAs, DNAs, non-code-DNAs, and epigenetics. There are also many things we don't understand about immunology. Since it was made by genetic engineering, they were planning to sell it as a "vaccine" to make money, using politics as well.
There are still things being planned that not only we, but even the pharmaceutical companies themselves, do not understand how they will work or what side effects they will have.
Moderna's strategy
mRNA-1273 = SpikeVax; for SarsCov2
mRNA-1189; for EBV
mRNA-1354; for RSV
mRNA-6981; for autoimmune hepatitis
mRNA-4157; for malignant melanoma
mRNA-5671; for non-small cell lung cancer
mRNA-4359; for stimulating effector T cells
mRNA-2752; for direct injection into tumors and lymphomas
mRNA-1468; for adult shingles
PatentSun's analysis is impressive, keep up the good work.
Kodansha BlueBacks: B2221 (Kenta Nakai), B2034 (Takehiko Kobayashi), B2262 (Akira, Kurosaki) are cheap and offer a wide field of vision.
Excellent analysis.
I have been thinking there has been a trade off for about a year now, but your discovery of the patent and the publishing of it by BioNTech scientists confirmed it for me. Although many say the LNPs or endotoxin are the adjuvants, I believe it is either dsRNA or rDNA that are acting as the adjuvants.
So the manufacturers NEED to have it a little bit "dirty" in order to get an immune response.
Pardi says it himself here: https://www.ema.europa.eu/en/documents/presentation/presentation-innate-immune-mechanisms-mrna-vaccines-rein-verbeke-et-al_en.pdf
I write about it in my very first substack though I didn't know about the IVT method used by BioNTech.
https://mariagutschi.substack.com/p/a-washed-up-pharmacists-musings
See also the brilliant work by Ganna Petruk and her team showing the intimate binding of mRNA, dsDNA to Endotoxin and the impact on casualty rates. They deserve a Nobel Prize.
https://portal.research.lu.se/en/persons/ganna-petruk
discussed in
https://geoffpain.substack.com/p/gmo-spike-protein-carries-e-coli
and
https://geoffpain.substack.com/p/covid19-deaths-and-ongoing-symptoms
and
https://geoffpain.substack.com/p/late-migrating-species-in-pfizer
When reading books by cutting-edge specialists, there are still many things we don't understand about various RNAs, DNAs, non-code-DNAs, and epigenetics. There are also many things we don't understand about immunology. Since it was made by genetic engineering, they were planning to sell it as a "vaccine" to make money, using politics as well.
There are still things being planned that not only we, but even the pharmaceutical companies themselves, do not understand how they will work or what side effects they will have.
Moderna's strategy
mRNA-1273 = SpikeVax; for SarsCov2
mRNA-1189; for EBV
mRNA-1354; for RSV
mRNA-6981; for autoimmune hepatitis
mRNA-4157; for malignant melanoma
mRNA-5671; for non-small cell lung cancer
mRNA-4359; for stimulating effector T cells
mRNA-2752; for direct injection into tumors and lymphomas
mRNA-1468; for adult shingles
PatentSun's analysis is impressive, keep up the good work.
Kodansha BlueBacks: B2221 (Kenta Nakai), B2034 (Takehiko Kobayashi), B2262 (Akira, Kurosaki) are cheap and offer a wide field of vision.